Research
- Colombia accounts for 0.017% of global cancer research.
- The growth rate of cancer research in Colombia is 12% per year (lower than the mean for LATAM).
- Colombia is fifth in cancer research productivity in LATAM.
- The country has reached the professional critical mass for science management in cancer.
- Over the next decade, CTIC will contribute to the transformation of the natural history of cancer research in Colombia and Latin America.
Through basic ,translational and clinical research, at CTIC we generate top-quality scientific knowledge that paves the way towards better health outcomes, contributing to comprehensive control of cancer through the production of new models that add value to prevention, diagnosis and treatment of neoplastic diseases.
Specific objectives
To implement research processes that meet the health needs of cancer patients in Colombia.
To promote local, regional and international inter-institutional cooperation and exchange, in order to facilitate and expand cancer research in Colombia.
Types of research
It aims to gain knowledge of reality or natural phenomena (at a cellular level in cancer) in order to further the advancement of society and better respond to the challenges facing mankind.
It allows convergence between basic research — aimed at solving biomedical problems — and preclinical, clinical and implementation research. The aim is to integrate knowledge through progressive transdisciplinary development and to apply and transfer the knowledge derived from basic research into clinical practice and, ultimately, in public health.
A branch of health sciences that determines the safety and efficacy (effectiveness) of drugs, devices, diagnostic products and treatment regimens for use in humans. These can be used for prevention, treatment, diagnosis or the relief of disease symptoms.
Based on the work of our researchers, we now have 94 publicationsin different specialized media.
Publications according to the Q* index*
*Each thematic category in the journals is divided into four quartiles: Q1, Q2, Q3, Q4. Q1 includes 25% of the most prestigious journals of the list; Q2 corresponds to journals in the 25 to 50% group; Q3, journals of the 50 to 75% group, and Q4 corresponds to journals of the 75 to 100% group . The most prestigious journals in a theme area are those that are part of the first quartile.
Institutional h-index: 9.56
This is a system proposed by Jorge Hirsch, from the University of California, to measure professional quality. It is an indicator used to evaluate the scientific production of a particulaar researcher. It allows to find the balance between the number of publications and the number of citations. This indicator is also applied to institutions and journals.
Institutional impact factor: 6.87
The Impact Factor measures the frequency with which the average article of a journal is cited in a particular year.
It is the most widely used bibliometric index. It is used to compare journals and assess the relative importance of a specific journal in a given scientific field.
Some publications:
- De Miguel-Perez D, Ortega FG, Tejada RG, Martínez-Única A, Peterson CB, Russo A, et al. Baseline extracellular vesicle miRNA-30c and autophagic CTCs predict chemoradiotherapy resistance and outcomes in patients with lung cancer. Biomark Res. 15 de noviembre de 2023;11(1):98. https://doi.org/10.1016/j.jtho.2022.02.015
- Zhang Y, Wu J, Qin T, Xu Z, Qu S, Pan L, et al. Comparison of the revised 4th (2016) and 5th (2022) editions of the World Health Organization classification of myelodysplastic neoplasms. Leukemia. diciembre de 2022;36(12):2875-82. https://doi.org/10.1016/S1470-2045(22)00404-1
- Parada-Gereda HM, Tibaduiza AL, Rico-Mendoza A, Molano-Franco D, Nieto VH, Arias-Ortiz WA, et al. Effectiveness of diaphragmatic ultrasound as a predictor of successful weaning from mechanical ventilation: a systematic review and meta-analysis. Crit Care. 5 de mayo de 2023;27(1):174. https://doi.org/10.1158/1078-0432.CCR-22-1912
- Lara-Mejía L, Cardona AF, Mas L, Martin C, Samtani S, Corrales L, et al. Impact of Concurrent Genomic Alterations on Clinical Outcomes in Patients With ALK-Rearranged NSCLC. Journal of Thoracic Oncology. enero de 2024;19(1):119-29. https://doi.org/10.1186/s13054-023-04430-9
- Llovet JM, Kudo M, Merle P, Meyer T, Qin S, Ikeda M, et al. Lenvatinib plus pembrolizumab versus lenvatinib plus placebo for advanced hepatocellular carcinoma (LEAP-002): a randomised, double-blind, phase 3 trial. The Lancet Oncology. diciembre de 2023;24(12):1399-410. https://doi.org/10.1016/j.jtho.2023.08.007
- Cardona AF, Mejía SA, Viola L, Chamorro DF, Rojas L, Ruíz-Patiño A, et al. Lung Cancer in Colombia. Journal of Thoracic Oncology. agosto de 2022;17(8):953-60. https://doi.org/10.2967/jnumed.122.265340
- Perini GF, Idrobo H, Oliver C, Von Glasenapp SA, Castro D, Villela Martinez LM, et al. Primary CNS Lymphoma in Latin America: A Grupo De Estudio Latinoamericano De Linfoproliferativos (GELL) Survey in 80 Cancer Centers in Latin America. Blood. 28 de noviembre de 2023;142(Supplement 1):2422-2422. https://doi.org/10.1182/blood-2023-190477
- Kayal G, Barbosa N, Marín CC, Ferrer L, Fragoso-Negrín JA, Grosev D, et al. Quality Assurance Considerations in Radiopharmaceutical Therapy Dosimetry Using PLANETDose: An International Atomic Energy Agency Study. J Nucl Med. enero de 2024;65(1):125-31. https://doi.org/10.1038/s41375-022-01718-7
- Sarria GR, Martinez DA, Del Castillo R, Salgado A, Pinillos L, Felix A, et al. Radiotherapy and cancer status in Latin America: economic analysis of investment opportunities up to 2030. The Lancet Oncology. julio de 2022;23:S5. https://doi.org/10.1186/s40364-023-00544-y
- Blaquier JB, Ortiz-Cuaran S, Ricciuti B, Mezquita L, Cardona AF, Recondo G. Tackling Osimertinib Resistance in EGFR-Mutant Non–Small Cell Lung Cancer. Clinical Cancer Research. 15 de septiembre de 2023;29(18):3579-91. https://doi.org/10.1016/S1470-2045(23)00469-2
In-house researchers
Based on the work of our medical and clinical staff we have made 268 presentations in different regional and international oncology events.
Some presentations
San Antonio Breast Cancer
- Pathological complete response (ypCR) in early and locally advanced breast cancer (LABC) patients treated with neoadjuvant chemotherapy in a middle-income country. Results from a real-world historical cohort
IGCS 2023 Annual Global Meeting, Seoul, South Korea
- Preoperative brachytherapy for early stage cervical cancer
European Lung Cancer Conference 2023
- Suppression of mutant Kirsten-RAS (KRAS G12C) non-small cell lung cancer (NSCLC) resistance to KRAS G12C inhibitors by dual inhibition of hepatocyte growth factor receptor (MET) and V-ATPase
- Omeprazole followed by tepotinib in sotorasib resistant-mutant-KRAS G12C non-small cell lung cancer (NSCLC) cell lines and one patient-derived organoid
- Genomic profiling of tissue and blood predicts survival outcomes in patients with resected malignant pleural mesothelioma
American Society of Clinical Oncology
- Real-World Characteristics and Outcomes of ERBB2-Mutant Non-Small Cell Lung Cancer in Latin America Patients
- Characteristics of SARSCOV2 infection in vaccinated patients with cancer in one Latin American country: Real world evidence from ACHOCC19-VAC study
2023 World Conference on Lung Cancer
- The MET inhibitor tepotinib potentially inhibits KRAS G12C and SHOC2 in KRAS G12C non-small cell lung cancer (NSCLC)
- Study Evaluating Alectinib Pharmacokinetics in the Hispanic Population With Advanced ALK-Rearranged Non-small-Cell Lung Cancer
- Suppression of mutant Kirsten-RAS (KRAS G12C) non-small cell lung cancer (NSCLC) resistance to KRAS G12C inhibitors by dual inhibition of hepatocyte growth factor receptor (MET) and V-ATPase
- Hispanic Patients with Unresectable Stage III NSCLC under PACIFIC Protocol: Evidence of Interior Outcomes and Health Inequity
- Prognostic Value of TP53 Commutations Among Hispanic Patients with Advanced EGFR-positive NSCLC Treated with First Line Osimertinib
Consorcio Latinoamericano para la Investigación del Cáncer de Pulmón CLICaP
- Radiotherapy in early stage lung cancer
- Andvances management of brain metastases in lung cancer
- Novel biomarkers for NSCLC immunotherapy
- Neo and adjuvant therapy in EGFRm NSCLC
- NSCLC immunotherapy in PD-L1 high expressed
36th Annual Congress - Milan
- Safety of antitumor therapy in critically ill patients
- SAFETY OF ANTITUMORAL THERAPY IN PATIENTS IN INTENSIVE CARE
- Infection by multiresistan gram negative in hematooncological patients. Characterization in Latin America
ESMO Congress 2023
- Selinexor (XPO1 inhibitor) in Combination with Tepotinib (MET inhibitor) Potentially Inhibits SHOC2 and KRAS G12C in KRAS G12C Mutant Non-Small Cell Lung Cancer
Nanets 2023 Multidisciplinary Net Medical Simposio
- Thoracic NET
- Panel Discussion: overview of Current Local NET Care Scenario
- Panel Discussions: perspectives of collaborative work
- Oligometastatic disease in Neuroendocrine Tumors
- Oligometastatic disease in well-differentiated Neuroendocrine Tumors
- Clinical cases Discussion
- Metastatic neuroendocrine tumor to the breast
ABC Global Alliance
- News from abc 6, er positive her 2 negative
- Member of the consensus panel
- How to optimally treat patients with advanced/ metastatic breast cancer in visceral crisis
LALCA -Latin America Conference on Lung Cancer 2023
- Importance of Smoking Cessation in the Treatment of Lung Cancer Patient
- Clinical Research in Lung Cancer: Gaps and Opportunities
- Incidental Pulmonary Programs as a Complement for Lung Cancer Screening
- Combining Radiation Therapy with Targeted Therapy in Oligometastatic Disease
- Genomic Landscape of Primary-Resistance to Osimertinib among Hispanic Patients With EGFR-Mutant Non-Small-Cell Lung Cancer: Results of an Observational Longitudinal-Cohort Study
- High Extracellular Vesicle TGF-β & PD-L1 Predict Poor Outcomes in Patients With Non-small Cell Lung Cancer Undergoing Immune-Checkpoint Inhibitors
- Using DNA Next-Generation Sequencing in blood to Guide Therapy for Newly Diagnosed Stage IV Non-Small Cell Lung Cancer (NSCLC) Patients
- Molecular Markers for Immunotherapy
ESTUDIOS DE INTERVENCIÓN | CÓDIGO DEL PROTOCOLO | PATROCINADOR | PATOLOGÍA | INVESTIGADOR | APROBACIÓN CEI |
APROBACIÓN INVIMA |
20190341 | Amgen | CA Pulmón no escamoso celulas no pequeñas PDL - KRAS + | Luis Leonardo Rojas Puentes | Aprobado/ 1AGO2023 |
Sometido, pendiente aprobación | |
20210081 | Amgen | CA Colorectal naive, metastasico KRAS + | Carlos Eduardo Bonilla Gonzalez | En proceso de sometimiento | Pendiente sometimiento y aprobación | |
BO42777/BO43249 Horizon01 | Productos Roche SA | CA Pulmón celulas no pequeñas | Luis Leonardo Rojas Puentes | Aprobado/ 11JUL2023 |
Aprobado/ SEP2023 |
|
CO44657 - PIONERA | Productos Roche SA | CA Mama | William Armando Mantilla Durán | Aprobado/ 19SEP2023 |
Aprobado/ ENE2024 |
|
M18-868 | AbbVie | CA Pulmón no escamoso células no pequeñas - EGFR | Luis Leonardo Rojas Puentes | Aprobado/ 24ENE2024 |
Pendiente sometimiento y aprobación | |
WO43571 -Heredera | Productos Roche SA | CA de mama | Sandra Ximena Franco Millán | Aprobado/ 20JUN2023 |
Aprobado/ OCT2023 |
|
WO44263 - Inavo 122 | Productos Roche SA | CA de mama | Maria Alejandra Bravo Garzón | Aprobado/ 20JUN2023 |
Aprobado Invima ENE2024 | |
IM048-022 | Bristol Myers Squibb | Mieloma Múltiple | Virginia Abello Polo | Aprobado/ 13JUN2023 |
Sometido, pendiente aprobación | |
D9078C0001 - PACIFIC - 9 | Astrazeneca | CA Pulmón | Luis Leonardo Rojas Puentes | Aprobado/ 25JUL2023 |
Aprobado/ NOV2023 |
|
MK2870 - 007 | MSD | CA Pulmón | Jairo Andrés Zuluaga León | Aprobado/ 24ENE2024 |
Pendiente sometimiento y aprobación | |
MK2870 - 010 | MSD | CA de mama | Sandra Ximena Franco Millán | Sometido/ 01FEB2024 |
Pendiente sometimiento y aprobación |
Nombre de propuesta o protocolo |
Investigador principal |
Contacto |
Exposición a RADON en pacientes con cáncer de pulmón de células no pequeñas no relacionados a exposición directa a humo de tabaco, estudio piloto. Protocolo Icaros 0220 |
Leonardo Rojas |
lrojas@fctic.org |
Caracterización de los pacientes con tumores neuroendocrinos en población colombiana |
Paola Jiménez |
|
Espectro mutacional del cáncer de mama triple negativo y su relación con la respuesta a quimioterapia neoadyuvante. Estudio descriptivo en población colombiana. Estudio ICAROS 0121 |
Sandra Franco |
|
Impacto del microbioma oral en la respuesta a inmunoterapia en pacientes con cáncer de pulmón de célula no pequeña avanzado |
Andrés Cardona |
|
Evaluación molecular de Tumores Neuroendocrinos gastroenteropancreáticos en población diagnosticada en FCTIC desde 2023-2028, mediante secuenciación de las mutaciones por next generation sequencing (NGS) en tejido tumoral. |
Paola Jiménez |
|
Comparación de dos estrategias de educación para el entrenamiento de pacientes y/o familiares que requieren administración segura de medicamentos vía subcutánea en casa |
Andrea Prada Álvarez |
|
Protocolo EVA-Biobanco Evidencia verificación y análisis |
Andres Cardona |
|
Registro epidemiológico de las cohortes de pacientes diagnosticados con neoplasias y enfermedades hematológicas en Colombia - RENEHOC. |
Virginia Abello |
|
Resultados clínicos del escalamiento de dosis de radioterapia en pacientes con adenocarcinoma de recto distal que reciben terapia neoadyuvante total |
Carlos Bonilla |
|
Construcción y validación de un instrumento para medir conocimientos, actitudes y prácticas frente a las terapias complementarias en pacientes oncológicos colombianos |
Leonardo Rojas |
|
Terapia neoadyuvante total (TNT) en pacientes con adenocarcinoma de recto, estudio de vida real |
Carlos Bonilla |
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Evaluación de la calidad de imagen [18F] FPSMA- 1007 con exploración de tiempo bajo utilizando un PET/CT digital |
Carlos Granados |
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Seguridad del tratamiento antitumoral en pacientes críticos oncológicos durante la hospitalización en unidad de cuidados intensivos |
Víctor Nieto |
|
Uso de azul de metileno en el manejo del choque séptico refractario en pacientes críticos con neoplasias hematológica o de órgano sólido en UCI en un centro oncológico de alta complejidad en Colombia |
Julián Mendoza |
|
Protocolo Estudio piloto para evaluar el valor percibido de una herramienta de narrativa gráfica para reducir la ansiedad previa al tratamiento en pacientes que reciben radioterapia en Colombia CEBRE |
Alejandro González |
|
Análisis de Impacto Presupuestal para el Sistema de Salud Colombiano de la participación de estudios clínicos patrocinados por privados |
Andrés Cardona |
|
Rendimiento pronóstico de 3 escalas para pacientes críticos con Cáncer en UCI en un centro oncológico de alta complejidad en Colombia |
Víctor Nieto |
|
Impacto de la utilización de dosis intermedias de citarabina en esquema acortado en pacientes con diagnóstico de leucemia mieloide aguda candidatos a terapias intensivas |
Paola Umaña |
|
Análisis de prevalencia, factores de riesgo y desenlaces clínicos en pacientes con Cáncer críticamente enfermos: Colonización por gérmenes productores de KPC e infecciones por Gérmenes Gram Negativos multidrogo resistentes |
Daniel Molano |
|
Costo -Efectividad PET CT PSMA en cáncer de próstata de alto riesgo |
Leonardo Rojas |
lrojas@fctic.org |
Más Allá del Tratamiento: Experiencia de Navegación en pacientes Oncológicos en la Fundación CTIC |
Elvy Milena Parra |
|
Aspectos socio demográficos del cáncer de tiroides en un centro de atención especializado en cáncer |
Roger Baquero |
|
Percepción de los pacientes con cáncer respecto a los estudios clínicos |
Liliana Gutiérrez |
|
Determinación de frecuencias de las alteraciones genéticas y composición del microbioma oral en el mesotelioma pleural maligno de una población colombiana expuesta a fibras de asbesto por medio de secuenciación del exoma completo |
Andrés Cardona |
|
Respuesta patológica peritoneal en pacientes con cáncer de ovario y carcinomatosis manejadas con quimioterapia neoadyuvante con intención curativa. |
Silvia Guerrero Macías |
|
Correlación de pacientes con bocio tiroideo y cáncer de tiroides sometidos a tiroidectomía |
Roger Baquero |
|
Cáncer de tiroides en el CTIC: correlación clinico-patologica e imagenológica |
Eduardo Oliveros |
|
Correlación entre la clasificación Bethesda, TIRADS por ecografía y patología quirúrgica en carcinoma de tiroides |
Marc Pierre |
|
Caracterización epidemiológica y análisis de supervivencia de pacientes con adenocarcinoma gástrico atendidos en la Fundación CTIC – estudio de vida real. |
Carlos Bonilla |
|
Factores de riesgo para la colonización por microorganismos productores de carbapenemasas en pacientes con neoplasias hematológicas del CTIC. |
María José López Mora |
|
Prevalencia de depresión y ansiedad generalizada en pacientes oncológicos de consulta externa del CTIC |
Marcela Prada |
|
Salud Ósea pacientes con Cáncer de cérvix |
Claudia Cruz |
|
Experiencia de pacientes con leucemia linfoide aguda en recaída manejados con Blinatumomab en Colombia. |
Virginia Abello |
|
Respuesta patológica peritoneal en pacientes con cáncer gástrico y carcinomatosis manejados con quimioterapia con intención curativa |
Silvia Guerrero Macías |
|
Impacto en el tiempo total de tratamiento de radioterapia en pacientes con cáncer de cabeza y cuello de un programa de IGRT diaria |
Iván Andrés Bobadilla. |
|
Funcionalidad de los pacientes críticamente enfermos oncológicos al inicio y egreso de su estancia con intervención fisioterapéutica |
Sandra Rodríguez |
|
Registro de pacientes con cáncer y tuberculosis |
Liliana Gutiérrez |
|
Predictores de fracaso de la ventilación mecánica no invasiva en pacientes con cáncer en insuficiencia respiratoria: un estudio prospectivo |
Víctor Nieto |
What is EVA
Prospective, observational, descriptive study designed to gather and organize the clinical and biological information as well as multiple outcomes of our patient population at the Luis Carlos Sarmiento Angulo Cancer Treatment and Research Center (CTIC). With its information platform, this study will allow for dynamic data capture with logic independence, minimum redundancy and concurrent access by various users, maintaining data integrity and security, in order to evaluate the natural history of several neoplasms diagnosed and treated in a real world setting. This will result in the ability to assess and solve essential cancer-related problems in Colombia.
How much have we accomplished?
- 47.770 Total variables created
- 2.043 Patients with Informed Consent
- 2.801 Total records delivered for entry into the data capture platform
- 43 Oncologic Disease Forms - FCU
- 6 FAU forms
- 25 Active institutional research studies nested in EVA
How do we do it?
Expected outputs
- Clinical data columns (DCs) for the main oncologic conditions (solid and hematologic tumors) related to complications secondary to the course of the disease and its treatment, associated with oncologic support and quality of life.
- Databases for clinical-genomic information integration.
- Standardized protocols for the generation of statistical analysis plans (SAPs).
- Guides for selecting study cohorts.
- Required institutional reporting
- Integration of the clinical information with prospectively collected biological specimens kept in the CTIC biobank.
- Outcomes benchmarking with other institutions.
- Local, regional and international biomedical publications.
- Books.